Results
| PMID | 22587873 |
| Gene Name | MT-CO2 |
| Condition | Endometriosis |
| Association |
Associated |
| Mutation | (-765G/C polymorphism ) |
| Population size | 510 |
| Population details | 510 (268 women with advanced-stage endometriosis, 242 control women without endometriosis) |
| Sex | Female |
| Other associated phenotypes |
Endomertiosis |
|
Am J Reprod Immunol. 2012 Sep;68(3):238-43. doi: Kim, Hye Yeon| Cho, Sihyun| Choi, Young Sik| Yang, Hyo In| Lee, Kyung Eun| Seo, Seok Kyo| Lee, Byung Seok Department of Obstetrics and Gynecology, Gangnam Severance Hospital, Yonsei University College of Medicine, Seoul, Korea. PROBLEM: We investigated the association of COX -2 gene-765G/C polymorphism and risk of advanced-stage endometriosis in Korean women. METHOD OF STUDY: This study consisted of 268 women with advanced-stage endometriosis and 242 control women without endometriosis in Korea. Subjects were genotyped for the -765G/C polymorphism of the COX -2 gene by RFLP-PCR analysis. RESULTS: There were significant differences in the genotype distributions of the -765G/C polymorphism between patients with advanced-stage endometriosis and control subjects. The C allele for -765G/C was associated with significantly lower risk of advanced-stage endometriosis (OR, 0.14; 95% CI, 0.06-0.30). CONCLUSIONS: We have demonstrated a significant genetic association between the -765G/C polymorphism and advanced-stage endometriosis in Korean women. The -765C allele may be protective against the development of the disease in Korean women. Mesh Terms: Adolescent| Adult| Alleles| *Asian Continental Ancestry Group| Case-Control Studies| Cyclooxygenase 2/*genetics| Endometriosis/ethnology/*genetics/pathology| Endometrium/*metabolism/pathology| Female| Gene Frequency| Genetic Predisposition to Di |
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